Detect and monitor vascular injury with PerkinElmer’s In Vivo Fluorescent Imaging Agents Panel. Vascular injury can have numerous causes, including peripheral vascular disease, thrombosis, aneurysm, atherosclerosis, and drug induced vascular injury. Vascular injury may progress into changes in vascular integrity, remodeling, inflammation, and fibrosis. This panel of fluorescent imaging probes detects cellular and molecular players in vascular pathology, allowing the ability to non-invasively characterize biological changes associated with disease progression or treatment efficacy. The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals. The Vascular In Vivo Fluorescent Agents Panel includes the following five probes: NEV10054EX - AngioSense 680 EX (Vascular probe: Provides vascular contrast or vascular leak imaging)NEV10168 - MMPSense 750 FAST (Pan-MMP activatable probe: Secreted protease involved in vascular remodeling and angiogenesis, Secreted by vascular inflammatory cells) NEV10645 - IntegriSense 680 (αVβ3 integrin targeted probe: Marker on neovasculature and inflammatory cells involved in vascular inflammation) NEV11112 - Cat B 680 FAST(Cathepsin B activatable probe: Lysosomal marker of cells in vascular inflammation) NEV11171 - ProSense 750 FAST (Pan-cathepsin activatable probe: Lysosomal marker of inflammatory cells in vascular inflammation)For research use only. Not for use in diagnostic procedures.
