Enhance your research with fluorescent probes targeting inflammation biology.
IVISense™ Inflammation fluorescent imaging panel enables in vivo visualization and quantification of inflammation biology. The ability to non-invasively quantify inflammation biology in vivo offers greater opportunity for longitudinal studies necessary to better understand disease pathogenesis in the context of intact animal physiology.
Inflammation is a complex biological response to stimuli presented by pathogens, tissue damage, or local irritants and involves a variety of immune cells that work to remove and repair the original insult and damaged tissue regions. Our fluorescent imaging probes provide a variety of tools for quantifying inflammatory biology (various proteases or upregulated receptors) as well as detecting and measuring the edema response. The ability to non-invasively quantify inflammation biology in vivo offers greater opportunity for longitudinal studies and understanding disease pathogenesis in the context of intact animal physiology.
The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals.
IVISense inflammation fluorescent imaging panel includes the following six probes
| Part number | Fluorescent probe | Biological target |
|---|
| NEV10054EX | IVISense Vascular 680 (AngioSense 680EX) | Vascular probe:
Leaks into sites of edema |
| NEV10168 | IVISense MMP 750 FAST (MMPSense 750 FAST) | Pan-MMP activatable probe:
Secreted marker of neutrophils, macrophages, and mast cells |
| NEV10040 | IVISense Folate Receptor 680 (FolateRSense 680) | Folate receptor targeted probe:
Marker on activated neutrophils and macrophages |
| NEV10873 | IVISense Integrin Receptor 750 (IntegriSense 750) | αVβ3 integrin targeted probe:
Marker on activated macrophages |
| NEV11169 | IVISense Neutrophil Elastase 680 FAST | Neutrophil elastase activatable probe:
Secreted protease from neutrophils |
| NEV11171 | IVISense Pan Cathepsin 750 FAST (ProSense 750 FAST) | Pan-cathepsin activatable probe:
Lysosomal marker of a variety of inflammatory cells |
For research use only. Not for use in diagnostic procedures.
