Detect molecular players in arthritis pathology with PerkinElmer’s In Vivo Arthritis Fluorescent Imaging Agent Panel. The biology of arthritis is complex, involving multiple cellular players, secreted factors, and processes that can lead to sever joint damage. Our fluorescent imaging probes targeting arthritis research allows in vivo imaging of the magnitude of inflammation, bone destruction, cartilage degradation, and vascular leak (edema) in a manner that non-invasively predicts the underlying histopathology of this disease. The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals. The Arthritis In Vivo Fluorescent Agents Panel includes the following six probes:NEV10003 - ProSense 680 (Pan-cathepsin activatable probe: Lysosomal marker of inflammatory cells)NEV10011EX- AngioSense 750 EX (Vascular probe: Leaks into sites of edema) NEV10020EX- OsteoSense 680 EX (Bone turnover targeted probe: Detects areas of exposed hydroxyapatite) NEV10126 - MMPSense 680 (Pan-MMP activatable probe: Secreted marker of inflammatory cells, bone/cartilage degradation)NEV11000 - CAT K 680 FAST (Cathepsin K activatable probe: Secreted marker of osteoclasts, bone degradation) NEV11098 - CAT B 750 FAST (Cathepsin B activatable probe: Lysosomal marker of inflammatory cells)For research use only. Not for use in diagnostic procedures.
